Alfie Mawson couldn't prevent Wycombe Wanderers exiting the Johnstone's Paint Trophy at the first hurdle after a 1-0 defeat against Coventry City at Adams Park.
Josh McQuoid scored the only goal of the game midway through the second half as Coventry secured their progress to the Second Round.
Tuesday's match was Alfie's seventh consecutive start for The Chairboys since he joined them on loan in August, and in total Alfie has missed just eight minutes of competitive action so far this campaign.
Alfie was the only Brentford player in action this week as Will Grigg was not named in MK Dons squad for their friendly against Leicester City.
Dagenham & Redbridge received a bye to the Second Round of the Johnstone's Paint Trophy meaning no midweek game for Josh Clarke.
Alfie and Josh will be hoping to be in action on Saturday as Wycombe host Bury while Dagenham & Redbridge host Northampton Town while MK Dons match against Sheffield United has been postponed due to international call-ups.