Keane signed his first professional contract for Hull City in February 2018 days after his seventeenth birthday, after goals for the youth team and under-23 side. His strong form continued into the 2018/19 season and led to his debut in the FA Cup at Millwall in January 2019.

In November 2019 Keane scored his first goal for City, and he continued to make a positive contribution during the 2019/20 season.

Keane started the 2021/22 season in impressive form, scoring goals in each of the first two games against Preston and Wigan, and he went on to start every game of the season.

In March 2022 Keane was selected for the England Under-21 squad. He won his first Under-21 cap when he came on as a late substitute against Albania. He was called up again in June 2022, and scored his first U21 goal for England two minutes into his first international start against Kosovo. He won his third U21 cap three days later against Slovenia.

Growing up, Keane supported Hull and Manchester United. His favourite footballers, past and present, are Wayne Rooney and Cristiano Ronaldo. Keane's footballing idol is also Wayne Rooney. Outside of football, Keane enjoys golf and snooker. He has also hit a 180 in darts! His favourite video game is Super Mario (Wii), and he also plays FIFA as PSG. His favourite food would either be pizza or cheesy chips!