Gareth Ainsworth’s side are gearing up for a first ever season in the second tier following their 2-1 Sky Bet League One Play-Off Final victory over Oxford United in June.
Both sides exited the competition on penalties at the First Round stage last season following 1-1 draws, The Bees to Cambridge United while Wycombe went out to Reading.
The two sides have never met in the EFL Cup and we last hosted The Chairboys back in January 2012; Gary Alexander netting a hat-trick in a 5-2 victory.
Further match details will be announced ahead of the fixture.
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