Gustav Mogensen had got the side back in the game after they had fallen behind early in the first half, but The Hatters claimed the win following a second half strike on the hour mark.
The 90 minutes provided a good opportunity for players to get more minutes under their belts with Wraynel Hercules coming in from the start, as well as the likes of Aubrel Koutsimouka, Ben Hockenhull and Gustav Mogensen all getting good game time, among four Trialists who featured.
It was a match which saw Town go ahead on 10 minutes, despite some good early play from The Bees who looked promising down the left when Koutsimouka flashed a cross into the box, but nobody was able to get on the end of it.
That opening goal came, arguably, against the run of play when a ball into the box wasn’t dealt with before Dion Pereira tapped in from close range.
After the early setback Brentford B continued to dominate possession but no clear-cut chances came within the opening 30 minutes. Then a moment of real quality saw a well-worked move find Hercules who curled an effort towards the top corner which the keeper saved, but he could only direct the ball into the path of Mogensen who found the net first time.
The goal came in perhaps what was the best spell for The Bees, but they were unable to make their dominance count with Luton forced to defend a number of balls into the box going into the break.
Winterbottom would be called into action on 56 minutes when he pulled off an excellent save to deny Solomon Addy, who darted into the box, and with Koutsimouka unable to challenge because of the risk of giving away a penalty, the Brentford keeper was out quick to deny the Luton man as he pushed the ball past the post.
A major moment in the game then saw The Bees denied another goal when a low ball into the box saw Mogensen turn an effort towards goal but for an excellent save from the Town keeper as he kept out the powerful attempt. There were also calls for a penalty in the build-up to the chance with calls for handball, but the referee waved away the appeals.
The Bees were then punished a moment later when a deep free-kick once again wasn’t dealt with and Sam Beckwith pounced on a loose ball to fire home.
Neil MacFarlane’s side kept battling to try to get something out of the game and Valgeir Valgeirsson continued to threaten down the right with some really dangerous deliveries. Another cross from the right would see Koutsimouka head just over with a powerful attempt which just lacked the accuracy. A late Ben Hockenhull red card for two bookable offences would precede the final whistle in a game where, in fairness, The Bees perhaps deserved at least a draw from.
Brentford B: Winterbottom, Valgeirsson, Gordon, Koutsimouka (Robb, 85), O’Connor, Trialist (Carre, 63), Mogensen, Hercules (Trialist, 75), Trialist (Trialist, 63), Stevens, HockenhullSubs not used: J. Thompson
Luton Town XI: Horlick, Jones, Francis, Panter, Halsey, Beckwith, Chambers, McJannett, Addy, Pererira, TrialistSubs: Cowler, Wedd, Allen, Newton, Nicolson, Wilson, Tompkins, Stevens